INDOLE

Indole is used as an electron donor moiety in synthesizing dyes for organic photovoltaics. The Indole nucleus is an important element of many natural and synthetic molecules with significant biological activity. This review covers some of the relevant and recent achievements in the biological chemical and pharmacological activity of important indole derivatives in the area of drug discovery and analysis.

Indole & their derivatives are promising agents tuberculosis, malaria, diabetes, cancer, migraines, convulsions, hypertension, bacterial infection of methicillin resistant and even eye viruses.

Particular Description
CAS NO. 120-72-9
FORMULA C8H7N
MOLECULAR WEIGHT 117.15079000

Specification

Particular Description
Product Name 1H-Indole
Other Names 3-Benzopyrrole, ketole,1H-benzazole
Appearance Snow White Crystals
Odour
Feces or jasmine like
Assay 97.00 to 100.00
Purity 99.5 % Minimum
Density 1.1747 g/cm3, solid
Boiling Point 253 – 254 C
Melting point 51 – 53 C
Flash Point 121 °C (250 °F; 394 K)
Solubility in water 0.19 g/100 ml (20 °C) Soluble in hot water
Storage Store in a cool or dry place ( Store below +30°C ).
Packaging 20 Kg Fibre Drum / 40 Kg Carton Box

Odor Strength

high ,recommend smelling in a 1.00 % solution or less.

Storage

Store in a Cool and dry place.

Indole Alkaloids

Reserpine

Antihypertensive – to treat agitated psychotic conditions

Vinca alkaloids

Anticancer agents.

Ergot Alkaloids

1-   Ergometrine – to prevent bleeding after childbirth ( smooth muscle constriction effect ).

2 –  Ergotamine – Used in Migraine

Indole Drug examples

BIOLOGICAL IMPORTANCE OF INDOLE

As antimicrobials

As anti-inflammatory agents

As antitumor agents

As antiviral agents

As hypocholesterolemic agent

As anticancer agents

As antihistamines

As antioxidants

As anti-diabetic agents

As antiparkinsonian agents

General Uses of Indole

It is generally used as Drug intermediate, Agrochemical, Perfumery chemicals

Drugs

Indomethacin

Ergotamine

Frovatriptan

Ondansetron

Tadalafil

Medical Uses Of Indole

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