Drug Intermediates

No  Name Formula Industrial Use Taste & flavor
1  Indole  (  C8H7N )

1350

Drug Intermediate,

Pesticides

septic-like flavor
2 Para Cymene  ( C10H14 ) Food flavor & drug intermediate Jeera

INDOLE

Indole is used as an electron donor moiety in synthesizing dyes for organic photovoltaics.The Indole nucleus is an important element of many natural and synthetic molecules with significant biological activity. This review covers some of the relevant and recent achievements in the biological chemical and pharmacological activity of important indole derivatives in the area of drug discovery and analysis.

Indole & their derivatives are promising agents tuberculosis, malaria, diabetes, cancer, migraines, convulsions, hypertension, bacterial infection of methicillin resistant and even eye viruses.

Product Name 1H-Indole
Synonyms 3-Benzopyrrole, ketole,1H-benzazole
Empirical Formula C8H7N
Molecular Weight 117.15 GM/MOL
Odar Strong MothBall Naphthalene
Appearance White Crystals
Purity 99.5 % Minimum
Boiling Point 254’C
Melting point 51-54’C
CAS No 120-72-9
Packing 1kg, 25kg
Description Indole is an aromatic heterocyclic organic compound. It has a bicyclic structure, consisting of a six-membered benzene ring fused to a five-membered nitrogen-containing pyrrole ring. Indole is widely distributed in the natural environment and can be produced by a variety of bacteria.

Indole Alkaloids

Reserpine

Antihypertensive – to treat agitated psychotic conditions

Vinca alkaloids

Anticancer agents.

Ergot Alkaloids

1-   Ergometrine – to prevent bleeding after childbirth ( smooth muscle constriction effect ).

2 –  Ergotamine – Used in Migraine

Indole Drug examples

BIOLOGICAL IMPORTANCE OF INDOLE

As antimicrobials

As anti-inflammatory agents

As antitumor agents

As antiviral agents

As hypocholesterolemic agent

As anticancer agents

As antihistamines

As antioxidants

As anti-diabetic agents

As antiparkinsonian agents

General Uses of Indole

It is generally used as Drug intermediate, Agrochemical, Perfumery chemicals

Drugs

Indomethacin

Ergotamine

Frovatriptan

Ondansetron

Tadalafil

Medical Uses Of Indole

Para Cymene

p-Cymene is a naturally occurring aromatic organic compound. It is classified as an alkylbenzene related to monoterpene. Its structure consists of a benzene ring para-substituted with a methyl group and an isopropyl group. p-Cymene is insoluble in water, but miscible with organic solvents.

Product Name Para Cymene
Synonyms para-Cymene,4-Isopropyltoluene,4-Methylcumene, P Cymene
Empirical Formula  C10H14
Cas No 99-87-6
Molar Mass 134.222 g.mol-1
Density 0.857 g/m3
Flash point 47 C
Boiling point 177 C
Melting point –       68 C
Solubility in water 23.4 MG/L
Odar Fresh citrus
Appearance Colorless liquid
Storage Store in cool, dry places in tightly sealed countries, Protect the head light.
Shelf Life 12 Months
Packings 100kg, 200kg Drum.

Products & Informations

p-Cymene is transparent liquid, found in essential oils, and has a tang of terpenes with orange odor or carrot odor. It can be extracted from Dipentene on the reactions of dehydrogenation and disproportionation by Raney nickel or Pd/C as catalyst. In this method, it is easy to separate and have a higher yield than alkylation by Toluene. The great quality of p-Cymene used as material to synthesize Tonalide.

APPLICATIONS & USES

  • the great quality of p-Cymene used as material to synthesis Tonalide
  • food flavors
  • flavors of daily products, such as soaps, cleaning solvent
  • pharmaceutical ingredients, has expectorant, cough efficacy
×